PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bis(dimethylamino)acridine, 3,6-; (Acridine orange) | 494-38-2 |
3.10
4.10
3.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| C17.H19.N3 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 265.39 | S |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.090 | 0.98 | 5.9 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0083 | 0.090 | 0.54 |
Technical Basis
A review of limited sources identified mouse intravenous LD50 toxicity data that was selected as the TEEL-3 basis and evaluated using factors in Tables 3.2, 3.3, and 3.4. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse intravenous LD50 (27.3 mg/kg)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was based on HHR=3, while the current basis is acute toxicity data for 3,6-bis(dimethylamino(acridine, which is a more preferred source (LD50 > HHR). The Rev. 29A and current TEEL-2 and TEEL-1 methodology remain consistent, with the differences in values due to the change of the TEEL-3 basis.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse intravenous LD50 (27.3 mg/kg)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was based on HHR=3, while the current basis is acute toxicity data for 3,6-bis(dimethylamino(acridine, which is a more preferred source (LD50 > HHR). The Rev. 29A and current TEEL-2 and TEEL-1 methodology remain consistent, with the differences in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Acridine-orange.
Satonaka et al. 2006. Extra-corporeal photodynamic image detection of mouse osteosarcoma in soft tissues utilizing fluoro-visualization effect of acridine orange. Oncology 70; 465-473. Retrieved from: http://www.jarvm.com/articles/Vol10Iss2/Vol10%20Iss2Orito.pdf