A review of available sources identified mouse acute toxicity data (LDLo) for intraperitoneal and intravenous routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred route, a mouse intraperitoneal LDLo, was selected as the TEEL-3 basis (Section 3.3.2). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Mouse intraperitoneal LDLo (2500 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was rat oral LD50, not found during this review. Instead, the current TEEL-3 basis is available mouse intraperitoneal LDLo. The Rev. 29A and current TEEL-2 and TEEL-1 use the same methodology, with differences due to the change in TEEL-3.