PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bisphenol A; (4,4'-Isopropylidenediphenol) | 80-05-7 |
14.01
4.01
11.01
4.08
7.01
8.00
11.00
4.09
4.04
4.10
|
||||||||||
| Formula | Synonyms | |||||||||||
| C15H16O2 | 4,4^-ISOPROPYLIDENEDIPHENOL, 2,2'-BIS(4-HYDROXYPHENYL)PROPANE, 2,2-(4,4-DIHYDROXYDIPHENYL)PROPANE, 2,2-BIS(4-HYDROXYPHENYL)PROPANE, 2,2-BIS(P-HYDROXYPHENYL)PROPANE, 2,2-DI(4-HYDROXYPHENYL)PROPANE, 2,2-DI(4-PHENYLOL)PROPANE, 4,4'-(1-METHYLETHYLIDENE)BISPHENOL, 4,4'-BISPHENOL A, 4,4'-DIHYDROXDIPHENYLPROPANE, 4,4'-DIHYDROXY-2,2-DIPHENYLPROPANE, 4,4'-DIHYDROXYDIPHENYL-2,2-PROPANE, 4,4'-DIHYDROXYDIPHENYLDIMETHYLMETHANE, 4,4'-DIMETHYLMETHYLENEDIPHENOL, 4,4'-ISOPROPYLIDENDIPHENOL, 4,4'-ISOPROPYLIDENEBISPHENOL, 4,4'-ISOPROPYLIDENEBIS[PHENOL], BETA,BETA'-BIS(P-HYDROXYPHENYL)PROPANE, BETA-DI-P-HYDROXYPHENYLPROPANE, BIS(4-HYDROXYPHENYL) DIMETHYLMETHANE, BIS(4-HYDROXYPHENYL)PROPANE, BIS(P-HYDROXYPHENYL)PROPANE, BISPHENOL, BISPHENOL A, BPA 154, BPA 157, DIAN, DIANO, DIMETHYL BIS(P-HYDROXYPHENYL)METHANE, DIMETHYLMETHYLENE-P,P'-DIPHENOL, DIPHENYLOLPROPANE, HIDORIN F 285, IPOGNOX 88, ISOPROPYLIDENEBIS(4-HYDROXYBENZENE), NCI-C50635, P,P'-BISPHENOL A, P,P'-DIHYDROXYDIPHENYLDIMETHYLMETHANE, P,P'-DIHYDROXYDIPHENYLPROPANE, P,P'-ISOPROPYLIDENEBISPHENOL, P,P'-ISOPROPYLIDENEDIPHENOL, PARABIS, PARABIS A, PHENOL, 4,4'-DIMETHYLMETHYLENEDI-, PHENOL, 4,4'-ISOPROPYLIDENEDI-, PLURACOL 245, PROPANE, 2,2-BIS(P-HYDROXYPHENYL)-, RIKABANOL, UCAR BISPHENOL HP | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 228.29 | S | 153 | 25 | 1.195 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 5.0 | 110 | 640 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.54 | 12 | 69 |
Technical Basis
A review of available sources identified the following: a MAK-STEL and oral LD50 acute toxicity data (guinea pig, rat). A mouse LC was also found, however the lethality effect (e.g., LC50, LCLo) could not be determined, therefore the incomplete record was not further evaluated. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The rat oral LD50 was selected as the TEEL-3 basis. TEEL-2 values were derived according to Table 3.5. The MAK-STEL was selected as the TEEL-1.
• TEEL-1 = MAK-STEL (15-minute)
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (3250 mg/kg)
This review generated TEEL values comparable with Rev. 29A, with different sources. The Rev. 29A and current TEEL-3 bases are the same, a rat oral LD50, however current calculations resulted in a slightly lower value. The Rev. 29A TEEL-2 basis, a rat TDLo was not found during the current review. Instead, current values were derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 basis was a MAK-TWA x 3, while the current basis is a more preferred source, a MAK-STEL (Table 3.1).
• TEEL-1 = MAK-STEL (15-minute)
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (3250 mg/kg)
This review generated TEEL values comparable with Rev. 29A, with different sources. The Rev. 29A and current TEEL-3 bases are the same, a rat oral LD50, however current calculations resulted in a slightly lower value. The Rev. 29A TEEL-2 basis, a rat TDLo was not found during the current review. Instead, current values were derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 basis was a MAK-TWA x 3, while the current basis is a more preferred source, a MAK-STEL (Table 3.1).
References
Rat oral LD50. American Industrial Hygiene Association Journal., 28(301), 1967 [PMID:6032412]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Bisphenol-A.
Guinea pig oral LD¬50¬. Gigiena i Sanitariya. For English translation, see HYSAAV., 33(7)(25), 1968. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Bisphenol-A.
MAK-STEL. Retrieved from: https://onlinelibrary.wiley.com/doi/pdf/10.1002/9783527695539.oth1