Technical Basis
A review of available sources identified GHS hazard rating for boron carbide. In addition, available boron (CASRN: 7440-42-8) acute toxicity data was evaluated as a basis for boron carbide. Boron carbide is classified as an irritant (H315, H319, H335; Category 2 & 3) with acute inhalation toxicity (H332, Category 4); this indicates a mid-to-high level health hazard (Section 3.4.5), approximately equivalent to an HHR=2 (TEEL-3 = 790 mg/m3) and an HHR=3 (TEEL-3 = 79 mg/m3). Note that there are also reproductive hazards associated with this chemical, not considered (Section 3.3.2). A dog oral LD50 acute toxicity data for boron was evaluated using factors in Tables 3.2, 3.3, and 3.4, and a compound adjustment factor was applied (Section 3.2.2). The resultant TEEL-3 is within range expected from the health hazard analysis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = MW-adjusted dog oral LD50 (boron, CASRN: 7440-42-8, 310 mg/kg)
This review generated TEELs values developed using the same methodology and source as Rev. 29A. Minor differences in TEEL-1 and TEEL-3 values may be due to rounding.
References
GHS health hazard ratings and physical characteristics retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Boron-carbide
https://pubchem.ncbi.nlm.nih.gov/ghs/#_prec
Dog oral LD50 (boron). Retrieved from: Gigiena i Sanitariya. For English translation, see HYSAAV., 35(11)(11), 1970. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Boron.