PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bromo acetic acid, methyl ester | 96-32-2 | 2643 |
14.01
14.02
11.01
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C3.H5.Br.O2 | METHYL BROMOACETATE, BROMACÉTATE DE MÉTHYLE (DOT FRENCH), BROMOACETATO DE METILO (DOT SPANISH), BROMOACETIC ACID METHYL ESTER, CARBOMETHOXYMETHYL BROMIDE, METHYL 2-BROMOACETATE, METHYL ALPHA-BROMOACETATE, METHYL MONOBROMOACETATE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 152.99 | L | 145 | 1.616 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.90 | 9.9 | 59 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.14 | 1.6 | 9.4 |
Technical Basis
A review of available sources identified the following: mouse intravenous LDLo and rat oral LD50 acute toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route toxicity data, a rat oral LD50, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (300 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a mouse intravenous LDLo, while the current basis is a rat oral LD50, a more preferred species and route (rat > mouse, oral > intravenous). Additionally, the mouse LDLo is from a summary table from a 1958 report and the source could not be verified. The Rev. 29A and current TEEL-2/TEEL-1 used the same methodology, with differences due to the change in TEEL-3
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (300 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a mouse intravenous LDLo, while the current basis is a rat oral LD50, a more preferred species and route (rat > mouse, oral > intravenous). Additionally, the mouse LDLo is from a summary table from a 1958 report and the source could not be verified. The Rev. 29A and current TEEL-2/TEEL-1 used the same methodology, with differences due to the change in TEEL-3
References
Chemical description and mouse intranveous LDLo retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/60984
Rat oral LD50: https://echa.europa.eu/registration-dossier/-/registered-dossier/5590/7/3/2