PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bromoanisole, 3-; (1-Bromo-3-methoxybenzene) | 2398-37-0 |
4.00
3.00
|
||||||||||
| Formula | Synonyms | |||||||||||
| C7.H7.Br. O | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 187.03 | S | 211 | 1.49 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 12 | 130 | 790 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.6 | 17 | 100 |
Technical Basis
A review of available sources did not identify exposure limits or acute toxicity data for 3-bromoanisole. The reported GHS health hazard ratings (H315 and H319, Category 2; H335, Category 3) indicate a mid-level health hazard, approximately equivalent to an HHR=2. Analysts also evaluated similar chemicals, specifically 3-bromo-5-methoxyphenol (CASRN: 855400-66-7) and 1-bromo-3,5-dimethoxybenzene (CASRN: 20469-65-2); these reported similar GHS ratings as the chemical of interest. Considering this, analysts assumed an HHR=2 as the TEEL-3 basis (Section 3.4.5). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = HHR=2
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA for particles not otherwise specified (Section 3.5.2), from which the TEEL-2 and TEEL-3 were derived (Table 3.5). The current TEEL-3 basis is an assumed HHR=2, from analysis of GHS health hazard statements, from which TEEL-2 and TEEL-1 were derived (Table 3.5).
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = HHR=2
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA for particles not otherwise specified (Section 3.5.2), from which the TEEL-2 and TEEL-3 were derived (Table 3.5). The current TEEL-3 basis is an assumed HHR=2, from analysis of GHS health hazard statements, from which TEEL-2 and TEEL-1 were derived (Table 3.5).
References
Chemical information and GHS ratings: https://pubchem.ncbi.nlm.nih.gov/compound/3-Bromoanisole.
GHS ratings for 3-bromo-5-methoxyphenol (CASRN: 855400-66-7): https://pubchem.ncbi.nlm.nih.gov/compound/3-Bromo-5-methoxyphenol.
GHS ratings for 1-bromo-3,5-dimethoxybenzene (CASRN: 20469-65-2): https://pubchem.ncbi.nlm.nih.gov/compound/1-Bromo-3_5-dimethoxybenzene.