PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Bromobenzene; (Phenyl bromide) 108-86-1 2514
15.01
4.05
8.00
7.00
11.00
4.06
4.10
4.07
3.05
10.00
Formula Synonyms
C6H5Br BROMOBENZENE, BROMOBENCENO (DOT SPANISH), BROMOBENZÈNE (DOT FRENCH), BROMOBENZOL, MONOBROMOBENZENE, NCI-C55492, PHENYL BROMIDE, PHENYLBROMIDE
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
157.01 L -30.72 156.06 7.5 34.9 1.495 @ 20°C
PAC Values
PAC Values (Original Units: ppm)
PAC-1 PAC-2 PAC-3
7.2 79 470
Converted PAC Values (mg/m3)
PAC-1 PAC-2 PAC-3
46 510 3000
Technical Basis
A review of available data sources identified the following: rat and mouse oral LD50, mouse intraperitoneal LD50, and rat LC50 toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to the type of exposure, species, and route hierarchies stated in Sections 3.3.1, 3.3.2. The LC50 rat data is the most preferred data species and route. However, it is also the oldest (1975) and does not list the dose duration. The next most preferred toxicity data, by species and route, is a rat oral LD50 which is also more recent (1984). Of these, the rat oral LD50 was selected as the TEEL-3 basis because it is a complete record, is more current by greater than 5 years, and results in a more conservative TEEL-3 (Section 3.3.1). The TDLo was evaluated, but not selected because the toxicity end point did not meet the criteria outlined in the handbook (Section 3.2.2). Instead, TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (2383 mg/kg)
This review generated values that are inconsistent than those reported in Rev. 29A. In Rev. 29A, the TEEL-3 basis was a rat intraperitoneal LD50, however this review selected a TEEL-3 basis of a rat oral LD50 as the most current and preferred route of administration. The Rev. 29A TEEL-2 basis of a rat oral TDLo did not meet TEEL toxicity end-point criteria and was instead derived from the current TEEL-3.
References
Rat, oral LD50: Safety Data Sheet: https://www.michigan.gov/documents/deq/deq-rrd-chem-BromobenzeneDatasheet_527783_7.pdf ; National Technical Information Service (NTIS**) OTS0571670 (1984) via PubChem: National Center for Biotechnology Information (2023).. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Bromobenzene
Mouse, oral LD50: Gigiena Truda i Professional'nye Zabolevaniya (GTPZAB). Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR): 32(10),25 (1988) & 13(9),56 (1969); via PubChem: National Center for Biotechnology Information (2023). Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Bromobenzene
Mouse, intraperitoneal, LD50: Mutagenesis (MUTAEX). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK): 2,111 (1987); via PubChem: National Center for Biotechnology Information (2023). Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Bromobenzene
Rat, inhalation, LC50: Gigiena Truda i Professional'nye Zabolevaniya (GTPZAB). Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR): 19(9),36 (1975); via PubChem: National Center for Biotechnology Information (2023). Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Bromobenzene
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