A review of available sources did not identify exposure limits or acute toxicity data for alpha-bromotoluene. Analysts identified available acute toxicity data for a structurally similar chemical, m-bromotoluene (C7H7Br, CASRN: 591-17), including doses for rat (LC50) and mouse (LD50, intraperitoneal and oral routes). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Although an inhalation route is preferred, the rat LC50 was an incomplete record because the source and duration of exposure could not be verified (Section 3.3.1). Instead, a mouse oral LD50 for m-bromotoluene was selected as the TEEL-3 basis (Section 3.4.6). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse oral LD50 (m-bromotoluene, CASRN: 591-17-3, 1436 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rabbit LCLo not found during the current review. Instead, the mouse LD50 with the most preferred route (oral > intraperitoneal) was selected as the TEEL-3 basis. The Rev. 29A and current TEEL-2/TEEL-1 values used the same methodology, with differences due to the change in TEEL-3.