PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Butanedione, 2,3-; (Diacetyl) | 431-03-8 | 2346 |
15.01
11.01
15.02
4.08
7.01
8.00
7.00
11.00
4.02
10.00
|
|||||||||
| Formula | Synonyms | |||||||||||
| C.H3.C.O.C.O.C.H3 | DIACETYL, 2,3-BUTADIONE, 2,3-DIKETOBUTANE, 2,3-DIOXOBUTANE, BIACETYL, BUTADIONE, BUTANE-2,3-DIONE, BUTANEDIONE, DIACETILO (DOT SPANISH), DIACÉTYLE (DOT FRENCH), DIMETHYL DIKETONE, DIMETHYLGLYOXAL, UN 2346 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 86.1 | L | 88 | 56.8 | 25 | 0.990 @ 15°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.070 | 52 | 310 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.020 | 15 | 88 |
Technical Basis
A review of available sources identified the following: REL-TWA, REL-STEL, TLV-TWA, TLV-STEL, and LD50 toxicity data (rat, rabbit, guinea pig) for various routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2 and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route, rat oral LD50, was selected as the TEEL-3 basis. The TEEL-2 was calculated according to Table 3.5. The TLV-STEL was selected as the TEEL-1.
• TEEL-1 = TLV-STEL (0.02 ppm)
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (1580 mg/kg)
This review generated a TEEL-3 value consistent with Rev. 29A. The Rev. 29A TEEL-2 basis was a rat oral TDLo, not found during the current review; instead, the TEEL-2 was derived according to Table 3.5. The Rev. 29A and current TEEL-1 source are consistent; however, Rev. 29A incorrectly reports the TLV-STEL as the same value in both ppm and mg/m3, while the current TEEL-1 is reported after conversion to mg/m3.
• TEEL-1 = TLV-STEL (0.02 ppm)
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (1580 mg/kg)
This review generated a TEEL-3 value consistent with Rev. 29A. The Rev. 29A TEEL-2 basis was a rat oral TDLo, not found during the current review; instead, the TEEL-2 was derived according to Table 3.5. The Rev. 29A and current TEEL-1 source are consistent; however, Rev. 29A incorrectly reports the TLV-STEL as the same value in both ppm and mg/m3, while the current TEEL-1 is reported after conversion to mg/m3.
References
https://pubchem.ncbi.nlm.nih.gov/compound/2_3-Butanedione
Rat oral LD50: Food and Cosmetics Toxicology., 2(327), 1964. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/2_3-Butanedione.
TLV-STEL: https://www.osha.gov/chemicaldata/802