PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Butanenitrile; (Butyronitrile) | 109-74-0 | 2411 |
4.01
11.01
4.08
4.05
7.01
7.00
11.00
4.06
4.10
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C4.H7.N | BUTYRONITRILE, 1-CYANOPROPANE, BUTANENITRILE, BUTIRONITRILO (DOT SPANISH), BUTYRIC ACID NITRILE, BUTYRONITRILE (DOT FRENCH), CYANOPROPANE, GAMMA-BUTYRONITRILE, N-BUTANENITRILE, N-BUTYRONITRILE, N-PROPYL CYANIDE, PROPYL CYANIDE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 69.12 | L | -112.6 | 117 | 19.5 | 25 | 0.796 @ 15°C | 16500 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0003 | 1.2 | 6.9 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.00085 | 3.4 | 20 |
Technical Basis
A review of available sources identified the following: exposure limits (TLV-STEL, TLV-TWA) and acute toxicity data (LC50, LCLo¬, LD50) for several species and routes. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred route and duration data, a 1-hour mouse LC50, was selected as the TEEL-3 basis. TEEL-2 values were derived according to Table 3.5. The TLV-STEL was selected as the TEEL-1.
• TEEL-1 = TLV-STEL (0.0003 ppm)
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse LC50 (249 ppm/1H)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a 1-hour rat LCLo, which is a more preferred species (rat > mouse), but the current TEEL-3 basis, a 1-hour mouse LC50, is more preferred source (LC50 > LCLo, Table 3.1). The Rev. 29A and current methodology are consistent for TEEL-2, with differences due to the change in TEEL-3. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 is an occupational exposure limit.
• TEEL-1 = TLV-STEL (0.0003 ppm)
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse LC50 (249 ppm/1H)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a 1-hour rat LCLo, which is a more preferred species (rat > mouse), but the current TEEL-3 basis, a 1-hour mouse LC50, is more preferred source (LC50 > LCLo, Table 3.1). The Rev. 29A and current methodology are consistent for TEEL-2, with differences due to the change in TEEL-3. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 is an occupational exposure limit.
References
Clinical Toxicology., 18(991), 1981 [PMID:7318385]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/8008.
https://www.inchem.org/documents/icsc/icsc/eics1465.htm