A review of available sources identified multiple rat oral LD50 and rat LC50 toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1 Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). Although the inhalation data is most preferred, the rat LC50 study could not be verified, therefore the LD50 data was considered. Of the rat oral LD50 toxicity data, the most conservative data (2500 mg/kg), was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (2500 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a rat oral LD50 (3045 mg/kg) that was found in current review; however, the recommended value is based on more conservative rat oral LD50 data (2500 mg/kg) from ECHA.