PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acetamide | 60-35-5 |
2.00
4.08
5.10
4.10
3.10
7.00
11.00
7.01
16.01
16.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| C2H5NO | ACETAMIDE, ACETIC ACID AMIDE, ACETIMIDIC ACID, ETHANAMIDE, METHANECARBOXAMIDE, NCI-C02108 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 59.067 | S crystals | 80.16 | 222 | 25 | 1.159 @ -20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 7.3 | 230 | 1400 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.0 | 95 | 580 |
Technical Basis
A review of available sources identified the following: numerous rat and mouse LD50 toxicity data for various routes of administration and a TLV-TWA exposure limit. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route, a rat oral LD50 was selected as the TEEL-3 basis, and the TLV-TWA was selected as the TEEL-1 basis. The TEEL-2 value was derived according to Table 3.5.
• TEEL-1 = TLV-TWA (1 ppm) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (7000 mg/kg)
This review generated TEEL-2 and TEEL-3 values that are consistent with Rev. 29A. In Rev. 29A the TEEL-1 was derived from the fill gap adjustment factors, however this review found and used the TLV-TWA as the TEEL-1 basis.
• TEEL-1 = TLV-TWA (1 ppm) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (7000 mg/kg)
This review generated TEEL-2 and TEEL-3 values that are consistent with Rev. 29A. In Rev. 29A the TEEL-1 was derived from the fill gap adjustment factors, however this review found and used the TLV-TWA as the TEEL-1 basis.
References
Chemical information retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Acetamide
Rat oral LD50: Journal of Reproduction and Fertility., 4(219), 1962. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Acetamide
TLV-TWA: https://www.osha.gov/chemicaldata/831