A review of available sources identified rat and mouse oral acute toxicity data (LD50). AEGLs for cadmium (CASRN: 7440-43-9) and TEEL values for cadmium nitrite (CASRN: 7790-83-2) were considered to determine expected magnitude of TEELs for cadmium nitrate. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts selected most preferred route and species toxicity data for cadmium nitrate, a rat oral LD50, as the TEEL-3 basis. This resulted in a TEEL-3 approximately 10x that of cadmium nitrite, which is consistent with regulations. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (300 mg/kg)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEELs were molecular weight adjusted cadmium AEGLs; per Section 3.2.2, AEGLs may not be weight adjusted. Instead, analysts selected available acute toxicity data for cadmium nitrate as the TEEL-3 basis and derived TEEL-2 and TEEL-1 values according to Table 3.5.