A review of available sources identified acute toxicity data (LCLo, LD50) for several routes and species. AEGLs for cadmium (CASRN: 7440-43-9) were considered to determine expected magnitude of TEELs for cadmium(II) acetate. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts selected most preferred route and species toxicity data for cadmium(II) acetate, a rat LCLo, as the TEEL-3 basis and it was scaled to a 60-minute equivalent using the ten Berge equation (Section 3.3.4). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LCLo (128 mg/m3/2H)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEELs were molecular weight adjusted cadmium AEGLs; per Section 3.2.2, AEGLs may not be weight adjusted. Instead, analysts selected available acute toxicity data for cadmium(II) acetate as the TEEL-3 basis and derived TEEL-2 and TEEL-1 values according to Table 3.5.