PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cantharidin | 56-25-7 |
15.01
4.01
11.01
14.02
4.08
7.01
7.00
4.09
4.07
4.03
|
||||||||||
| Formula | Synonyms | |||||||||||
| C10.H12.O4 | CANTHARIDIN, 1,2-DIMETHYL-3,6-EPOXYPERHYDROPHTHALIC ANHYDRIDE, 2,3-DIMETHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3- DICARBOXYLIC AN, 4,7-EPOXYISOBENZOFURAN-1,3-DIONE, HEXAHYDRO-3A,7A-DIMETHYL-,, 4,7-EPOXYISOBENZOFURAN-1,3-DIONE, HEXAHYDRO-3A,7A-DIMETHYL-,, 7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC ANHYDRIDE, 2,3-D, CAN, CANTHARIDES CAMPHOR, CANTHARIDINE, CANTHARONE, EXO-1,2-CIS-DIMETHYL-3,6-EPOXYHEXAHYDROPHTHALIC ANHYDRIDE, HEXAHYDRO-3A ALPHA, 7A ALPHA-DIMETHYL-4 BETA, 7 BETA-EPOXYIS, KANTARIDIN | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 196.22 | S | 218 | 0.02 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.39 | 4.3 | 27 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.049 | 0.54 | 3.4 |
Technical Basis
A review of available sources identified a LOC and acute toxicity data (LDLo, LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Although there was a higher priority LD50 toxicity data available, it was the least preferred species and route (mouse intraperitoneal LD50) of the available data. The most preferable species data, a human oral LDLo, was considered for the TEEL-3 basis but was not selected for TEEL development because the sex was not specified (Section 3.3.1). Instead, the next most preferred species data, a dog oral LDLo, was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The TEEL-1 value was derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0043 g/m3)
• PAC-3 = TEEL-3 = Dog oral LDLo (50 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are both dog oral LDLo toxicity data; however, the current value is based on a more conservative dose. The Rev. 29A and current TEEL-2 and TEEL-1 values, methodology, and sources remain consistent.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0043 g/m3)
• PAC-3 = TEEL-3 = Dog oral LDLo (50 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are both dog oral LDLo toxicity data; however, the current value is based on a more conservative dose. The Rev. 29A and current TEEL-2 and TEEL-1 values, methodology, and sources remain consistent.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Cantharidin.
Human (sex unspecified) oral LDLo; Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969, (646), 1969. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Cantharidin
Dog oral LDLo: Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation, Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931, 1931. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Cantharidin.
LOC. Appendix C, pg. C-3. https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf