Technical Basis
A review of available sources identified no acute toxicity data or exposure limits for cerium (IV) nitrate. Reported GHS health hazard ratings (H315, Category 2; H318, Category 1) indicate a mid/high-level health hazard, approximately equivalent to an HHR=2 or HHR=3. In addition, analysts evaluated multiple rat oral LD50 toxicity data for a similar chemical, cerium(III) nitrate (Section 3.4.6, CASRN: 10108-73-3). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts evaluated two available rat oral LD50 toxicity dose reported for cerium trinitrate (4200 mg/kg and 3154 mg/kg); the most conservative dose was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (cerium(III) nitrate, CASRN: 10108-73-3; 3154 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA for particles not otherwise specified (Section 3.5.2), from which the TEEL-2 and TEEL-3 were derived (Table 3.5). The current TEEL-3 is a rat oral LD50 for a similar chemical (cerium trinitrate, Section 3.4.6), from which TEEL-2 and TEEL-1 values were derived (Table 3.5).
References
Chemical information: https://comptox.epa.gov/dashboard/chemical/details/DTXSID60890686
GHS health hazard statements retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/166767
Rat oral LD50 (4200 mg/kg) for cerium(III) nitrate (CASRN: 10108-73-3): https://chem.echa.europa.eu/100.030.257/dossier-view/1eaff088-1674-45c9-9ba4-e4f48c0cc799/IUC5-660e8e91-639a-481b-9bb0-9b2cefbce895_5673e624-9bef-44b8-9fc0-f8410bfdfefd?searchText=10108-73-3
Rat oral LD50 (3154 mg/kg) for cerium(III) nitrate (CASRN: 10108-73-3): Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975. Retrieved from CompTox (Access by clicking Hazard Data => Hazard => Mortality Response Summary Value): https://comptox.epa.gov/dashboard/chemical/details/DTXSID20881414