PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chloro-1,2-propanediol, 3-; (Chlorohydrin) | 96-24-2 | 2689 |
14.01
4.01
11.01
15.02
7.01
8.00
7.00
11.00
4.09
4.06
|
|||||||||
| Formula | Synonyms | |||||||||||
| C3.H7.Cl.O2 | GLYCEROL ALPHA-MONOCHLOROHYDRIN, 3-CHLORO-1,2-PROPYLENE GLYCOL, 3-CHLOROPROPANE-1,2-DIOL, 3-CHLOROPROPANEDIOL, 3-CHLOROPROPYLENE GLYCOL, ALFA-MONOCLOROHIDRINA DE GLICEROL (DOT SPANISH), ALPHA-CHLORHYDRIN, ALPHA-CHLOROHYDRIN, ALPHA-MONOCHLORHYDRINE DU GLYCÉROL (DOT FRENCH), ALPHA-MONOCHLOROHYDRIN, CHLORODEOXYGLYCEROL, CHLOROHYDRIN, CHLOROPROPANEDIOL, DL-ALPHA-CHLOROHYDRIN, EKOROD A, EPIBLOC, GLYCERIN ALPHA-MONOCHLORHYDRIN, GLYCERIN EPICHLOROHYDRIN, GLYCERIN MONOCHLOROHYDRIN, GLYCERINE ALPHA-MONOCHLOROHYDRIN, GLYCEROL 3-CHLOROHYDRIN, GLYCEROL ALPHA-CHLOROHYDRIN, GLYCEROL CHLOROHYDRIN, GLYCEROL MONOCHLOROHYDRIN, GLYCERYL ALPHA-CHLOROHYDRIN, GLYCERYL CHLORIDE, MONOCHLORHYDRIN, U 5897, U-5897, (.+-.)-2,3-DIHYDROXYCHLOROPROPANE, (.+-.)-3-CHLORO-1,2-PROPANEDIOL, (RS)-3-CHLORO-1,2-PROPANEDIOL, (RS)-ALPHA-CHLOROHYDRIN, 1,2-DIHYDROXY-3-CHLOROPROPANE, 1-CHLORO-1-DEOXYGLYCEROL, 1-CHLORO-2,3-DIHYDROXYPROPANE, 1-CHLORO-2,3-PROPANEDIOL, 1-CHLOROPROPANE-2,3-DIOL, 2,3-DIHYDROXYPROPYL CHLORIDE, 3-CHLORO-1,2-DIHYDROXYPROPANE, 3-CHLORO-1,2-PROPANEDIOL | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 110.55 | L | 0.2 | 20 | 1.326 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.015 | 0.89 | 5.4 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.068 | 4.0 | 24 |
Technical Basis
A review of available sources identified the following: a MAK-TWA, mouse LC50 and rat LCLo acute toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The most preferred species and route, a rat LCLo was selected as the TEEL-3 basis. The TEEL-2 was derived according to Table 3.5. The MAK-TWA was selected as the TEEL-1 basis.
• TEEL-1 = MAK-TWA (0.005 ppm) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LCLo (125 ppm/4H)
This review generated TEEL values inconsistent with those in Rev. 29A. The Rev. 29A and current TEEL-3 basis are consistent. The Rev. 29A TEEL-2 basis was a rat oral TDLo not found during the current review, while the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current value is based on an exposure limit (MAK-TWA).
• TEEL-1 = MAK-TWA (0.005 ppm) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LCLo (125 ppm/4H)
This review generated TEEL values inconsistent with those in Rev. 29A. The Rev. 29A and current TEEL-3 basis are consistent. The Rev. 29A TEEL-2 basis was a rat oral TDLo not found during the current review, while the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current value is based on an exposure limit (MAK-TWA).
References
MAK-TWA. https://onlinelibrary.wiley.com/doi/pdf/10.1002/9783527695539.oth1
Mouse LC50. AMA Archives of Industrial Health., 14(250), 1956. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/3-Chloro-1_2-propanediol.
Rat LCLo. Journal of Industrial Hygiene and Toxicology., 31(343), 1949 [PMID:15407114]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/3-Chloro-1_2-propanediol.