PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chloropropanol, 3-; (1-Propanol, 3-chloro-) | 627-30-5 | 2849 |
7.00
4.07
4.10
11.01
15.01
15.02
|
|||||||||
| Formula | Synonyms | |||||||||||
| C3.H7.Cl.O | 3-CHLOROPROPANOL-1, 1-CHLORO-3-HYDROXYPROPANE, 1-CHLORO-3-PROPANOL, 3-CHLORO-1-HYDROXYPROPANE, 3-CHLORO-1-PROPANOL, 3-CHLOROPROPANOL, 3-CHLOROPROPYL ALCOHOL, 3-CLORO 1-PROPANOL (DOT SPANISH), CHLORO-3 PROPANOL-1 (DOT FRENCH), TRIMETHYLENE CHLOROHYDRIN | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 94.55 | L | 165 | 1.309 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 6.0 | 41 | 250 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.6 | 11 | 65 |
Technical Basis
A review of available sources identified mouse oral LD50 toxicity data and an OEL-TWA (Latvia) exposure limit. Data sources were selected according to the hierarchy listed in Table 3.1. The mouse oral LD50 was selected as the TEEL-3 basis and evaluated using factors in Tables 3.2, 3.3, and 3.4. The TEEL-2 was derived according to Table 3.5. The OEL-TWA (Latvia) was selected as the TEEL-1 basis.
• PAC-1 = TEEL-1 = OEL-TWA (Latvia; 2 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Mouse oral LD50 (2300 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 that was not found in this review. Instead, the current TEEL-3 basis is a mouse oral LD50. The TEEL-2 methodology remains consistent, with the difference in values due to the change of the TEEL-3 basis. The Rev. 29A TEEL-1 was derived from the TEEL-2 (Table 3.5), while the current TEEL-1 basis is an exposure limit, OEL-TWA (Latvia).
• PAC-1 = TEEL-1 = OEL-TWA (Latvia; 2 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Mouse oral LD50 (2300 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 that was not found in this review. Instead, the current TEEL-3 basis is a mouse oral LD50. The TEEL-2 methodology remains consistent, with the difference in values due to the change of the TEEL-3 basis. The Rev. 29A TEEL-1 was derived from the TEEL-2 (Table 3.5), while the current TEEL-1 basis is an exposure limit, OEL-TWA (Latvia).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/3-Chloro-1-propanol.
OEL-TWA: https://ilv.ifa.dguv.de/limitvalues/13211
Mouse oral LD50: Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete., 26(17), 1980 [PMID:7415325]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/3-Chloro-1-propanol.