PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Colchicine | 64-86-8 | 1544 |
6.00
14.01
11.01
15.02
4.08
4.05
7.01
8.00
7.00
11.00
|
|||||||||
| Formula | Synonyms | |||||||||||
| C22.H25.N.O6 | COLCHICINE, (-)-COLCHICINE, 7-ACETAMIDO-6,7-DIHYDRO-1,2,3,10-TETRAMETHOXYBENZO(A)HEPTALE, 7-ALPHA-H-COLCHICINE, ACETAMIDE, ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10- TETRAMETHOXY-9-OX, ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXO, BENZO[A]HEPTALEN-9(5H)-ONE, 7-ACETAMIDO-6,7-DIHYDRO-1,2,3,10, BENZO[A]HEPTALENE, ACETAMIDE DERIV., COLCHICEINE METHYL ETHER, COLCHICENOS, COLCHINEOS, COLCHISOL, COLCIN, COLSALOID, CONDYLON, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEP, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(ALPHA, N-ACETYL TRIMETHYLCOLCHICINIC ACID, METHYL ETHER, N-ACETYLTRIMETHYLCOLCHICINIC ACID METHYL ETHER, N-[(7S)-5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZ(A, NSC 757 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 399.48 | S | 407 | 0.00001 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.082 | 0.90 | 1.9 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0050 | 0.055 | 0.12 |
Technical Basis
A review of available sources identified several human and animal toxicity data (LD50, LDLo, TDLo) for various routes, and a level of concern (LOC). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most current human (female) oral LDLo was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The TEEL-1 value was derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.0009 g/m3)
• TEEL-3 = Human (female) oral LDLo (3 mg/kg)
This review generated TEEL-1 and TEEL-2 values that are consistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50, however, LDLo data of a more preferred species (human > rat) was identified and used for the current TEEL-3 recommendation.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.0009 g/m3)
• TEEL-3 = Human (female) oral LDLo (3 mg/kg)
This review generated TEEL-1 and TEEL-2 values that are consistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50, however, LDLo data of a more preferred species (human > rat) was identified and used for the current TEEL-3 recommendation.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Colchicine.
LOC: Retrieved from Appendix C, page C-3; https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf
Human (female) oral LDLo: Japanese Journal of Toxicology., 12(337), 1999 via PubChem; National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 6167, Colchicine. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Colchicine.