PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cresols, all isomers; (includes 95-48-7,108-39-4,106-44-5) | 1319-77-3 | 2076 |
14.01
11.01
14.02
4.08
7.01
8.00
7.00
11.00
4.09
4.06
|
|||||||||
| Formula | Synonyms | |||||||||||
| C7H8O | CRESOLS, 1-HYDROXY-4-METHYLBENZENE, 1-METHYL-4-HYDROXYBENZENE, 3-CRESOL, 3-METHYLPHENOL, 4-CRESOL, 4-HYDROXYTOLUENE, 4-METHYLPHENOL, ACIDE CRÉSYLIQUE (DOT FRENCH), ACIDO CRESÍLICO (DOT SPANISH), AR-TOLUENOL, BACILLOL, COMPONENT 1 (60%): M-CRESOL, COMPONENT 2 (40%): P-CRESOL, CRESOL, CRESOL (MIXED ISOMERS), CRESOLES (DOT SPANISH), CRÉSOLS (DOT FRENCH), CRESYLIC ACID, CRESYLIC ACIDS, HYDROXYTOLUENE, HYDROXYTOLUENES, METHYLPHENOIS, METHYLPHENOL, OXYTOLUENES, P-CRESYLIC ACID, P-HYDROXYTOLUENE, P-KRESOL, P-METHYLHYDROXYBENZENE, P-METHYLPHENOL, P-OXYTOLUENE, P-TOLUOL, P-TOLYL ALCOHOL, PARA-CRESOL, PARAMETHYL PHENOL, RCRA WASTE NUMBER U052, TAR ACIDS, TEKRESOL, TRICRESOL, UN 2076 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 108.14 | L | 25 | 1.030 to 1.038 | 11000 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.0 | 25 | 250 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 4.4 | 110 | 1100 |
Technical Basis
A review of available sources identified exposure limits (TWAs, STELs, LOC, IDLH) and acute toxicity data for all cresol isomers. Data sources were selected according to the hierarchy listed in Table 3.1. The IDLH was selected as the TEEL-3. The LOC for o-cresol (CASRN: 94-48-7) was selected as the TEEL-2. The lowest OEL-STEL, a MAK-STEL (AGS, Germany; 15-minute) was selected as the TEEL-1.
• PAC-1 = TEEL-1 = MAK-STEL (1 ppm, 4.5 mg/m3)
• PAC-2 = TEEL-2 = LOC (o-cresol, CASRN: 95-48-7; 0.11 g/m3)
• PAC-3 = TEEL-3 = IDLH (1990, 250 ppm)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A, and a PAC-1 value inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA, while the current TEEL-1 is a MAK-STEL, a more preferred source (see note in Table 3.5).
• PAC-1 = TEEL-1 = MAK-STEL (1 ppm, 4.5 mg/m3)
• PAC-2 = TEEL-2 = LOC (o-cresol, CASRN: 95-48-7; 0.11 g/m3)
• PAC-3 = TEEL-3 = IDLH (1990, 250 ppm)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A, and a PAC-1 value inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA, while the current TEEL-1 is a MAK-STEL, a more preferred source (see note in Table 3.5).
References
Chemical information for o-cresol (CASRN: 94-48-7): https://pubchem.ncbi.nlm.nih.gov/compound/335
Chemical information for m-cresol (CASRN: 108-39-4): https://pubchem.ncbi.nlm.nih.gov/compound/342
Chemical information for p-cresol (CASRN: 106-44-5): https://pubchem.ncbi.nlm.nih.gov/compound/2879
IDLH: https://www.cdc.gov/niosh/idlh/cresol.html
LOC: Appendix C (pg. C-3). https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf
TWAs: https://www.osha.gov/chemicaldata/223
OELs: https://ilv.ifa.dguv.de/limitvalues/14993