PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cyanogen bromide | 506-68-3 | 1889 |
14.01
4.01
11.01
14.02
4.08
4.05
7.01
7.00
11.00
4.06
|
|||||||||
| Formula | Synonyms | |||||||||||
| BrCN | CYANOGEN BROMIDE, BROMINE CYANIDE, BROMINE CYANIDE (BRCN), BROMINE MONOCYANIDE, BROMOCYAN, BROMOCYANIDE, BROMOCYANIDE (BRCN), BROMOCYANOGEN, BROMURE DE CYANOGÈNE (DOT FRENCH), BROMURO DE CIANÓGENO (DOT SPANISH), CAMPILIT, CYANO BROMIDE, CYANOBROMIDE, CYANOGEN BROMIDE (BRCN), CYANOGEN MONOBROMIDE, TL 822 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 105.93 | S | 52 | 61.6 | 122 | 25 | 2.015 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 2.0 | 7.1 | 15 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 8.7 | 31 | 65 |
Technical Basis
A review of available sources identified exposure limits (OEL) and acute toxicity data (LCLo, LD50) for several species and routes. In addition, analysts evaluated exposure limits for cyanide (IDLH, ceiling limits; CASRN: 57-12-5) and hydrogen cyanide (AEGLs, CASRN: 74-90-8) for TEEL development. Analysts considered that 1) sources report the toxic actions and effects of cyanogen bromide as similar, but less severe, than hydrogen cyanide; as such, the AEGLs for hydrogen cyanide are more precautionary than MW-adjusted cyanide exposure limits, 2) AEGLs are the highest priority source for informing PACs (Section 1), and 3) available, chemical-specific acute toxicity is inconsistent in magnitude. Additionally, the chemical-specific LOC is comparable in magnitude as the AEGL-2 for hydrogen bromide, but a less preferred source (Section 1). Considering this, analysts selected the AEGLs for hydrogen cyanide due to their priority among Protective Action Criteria (Section 3.4.6, Section 1).
• PAC-1 = AEGL-1 (hydrogen cyanide; CASRN: 74-90-8)
• PAC-2 = AEGL-2 (hydrogen cyanide; CASRN: 74-90-8)
• PAC-3 = AEGL-3 (hydrogen cyanide; CASRN: 74-90-8)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was a weight adjusted the 1990 cyanide IDLH, the TEEL-2 was the LOC for cyanogen bromide, and the TEEL-1 was a weight adjusted MAK-TWA for cyanides. The current PACs are AEGLs for hydrogen cyanide (Section 3.4.6), due to its toxic effects being similar to those of hydrogen bromide.
• PAC-1 = AEGL-1 (hydrogen cyanide; CASRN: 74-90-8)
• PAC-2 = AEGL-2 (hydrogen cyanide; CASRN: 74-90-8)
• PAC-3 = AEGL-3 (hydrogen cyanide; CASRN: 74-90-8)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was a weight adjusted the 1990 cyanide IDLH, the TEEL-2 was the LOC for cyanogen bromide, and the TEEL-1 was a weight adjusted MAK-TWA for cyanides. The current PACs are AEGLs for hydrogen cyanide (Section 3.4.6), due to its toxic effects being similar to those of hydrogen bromide.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Cyanogen-bromide
Human toxicity effects summaries, retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Cyanogen-bromide#section=Human-Toxicity-Excerpts&fullscreen=true
Hydrogen cyanide AEGL: https://www.epa.gov/aegl/hydrogen-cyanide-results-aegl-program