PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cycloheximide | 66-81-9 | 2588 |
15.01
15.02
4.08
4.05
7.01
8.00
4.09
4.06
4.10
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C15.H23.N.O4 | CYCLOHEXIMIDE, 2,6-PIPERIDINEDIONE, 4-(2-(3,5-DIMETHYL-2-OXOCYCLOHEXYL)- 2-, 2,6-PIPERIDINEDIONE, 4-[2-(3,5-DIMETHYL-2-OXOCYCLOHEXYL)-2-H, 3-(2-(3,5-DIMETHYL-2-OXOCYCLOHEXYL)-2-HYDROXYETHYL)GLUTARIMI, ACTI-AID, ACTI-DIONE, ACTI-DIONE BR, ACTI-DIONE PM, ACTI-DIONE TGF, ACTI-DIONE-PM(-RZ,-BR,&-S), ACTIDION, ACTIDIONE, ACTIDIONE PM, ACTIDIONE TGF, ACTIDONE, ACTISPRAY, BETA-(2-(3,5- DIMETHYL-2-OXOCYCLOHEXYL)-2-HYDROXYETHYL)GLUTA, BETA-(2-(3,5-DIMETHYL-2-OXOCYCLOHEXYL)-2-HYDROXYETHYL)GLUTAR, CICLOHEXIMIDE, GLUTARIMIDE, 3-(2-(3,5-DIMETHYL-2-OXOCYCLOHEXYL)-2- HYDROXYE, GLUTARIMIDE, 3-[2-(3,5-DIMETHYL-2-OXOCYCLOHEXYL)-2-HYDROXYET, HIZAROCIN, KAKEN, NARAMYCIN, NARAMYCIN A, NEOCYCLOHEXIMIDE, NM-MCD 80, NSC 185, NSC-185, TZA, U 4527, U-4527 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 281.39 | S | 0.006 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.18 | 2.0 | 12 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.016 | 0.17 | 1.0 |
Technical Basis
A review of available sources identified the following: an LOC and LD50 for dog, mouse, rat, and monkey. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The monkey LD50 was the most preferred species and route, therefore it was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The TEEL-1 was derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.002 g/m3)
• TEEL-3 = Monkey oral LD50 (60 mg/kg)
This review generated TEEL values that are consistent with those in Rev. 29A.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.002 g/m3)
• TEEL-3 = Monkey oral LD50 (60 mg/kg)
This review generated TEEL values that are consistent with those in Rev. 29A.
References
Monkey oral LD50: Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 960. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1552
LOC: Appendix C, pg. C-3. https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf