PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Diaminodiphenylsulfone; (4,4'-Sulfonyldianiline) | 80-08-0 |
13.00
6.00
4.01
4.08
4.05
7.01
8.00
7.00
11.00
4.09
|
||||||||||
| Formula | Synonyms | |||||||||||
| C12.H12.N2.O2.S | 4,4^-SULFONYLDIANILINE, 1,1'-SULFONYLBIS(4-AMINOBENZENE), 1,1'-SULFONYLBIS[4-AMINOBENZENE], 1,1'-SULPHONYLBIS(4-AMINOBENZENE), 1358F, 4,4'-DAPSONE, 4,4'-DIAMINODIPHENYL SULFONE, 4,4'-DIAMINODIPHENYL SULPHONE, 4,4'-DIAMINOPHENYL SULFONE, 4,4'-SULFONYLBISANILINE, 4,4'-SULFONYLBISBENZAMINE, 4,4'-SULPHONYLBISBENZAMINE, 4,4'-SULPHONYLBISBENZENAMINE, 4,4'-SULPHONYLDIANILINE, 4-AMINOPHENYL SULFONE, ANILINE, 4,4'-SULFONYLDI-, ARALDITE HT 976, AVLOSULFON, AVLOSULPHONE, BENZENAMINE, 4,4'-SULFONYLBIS-, BIS(4-AMINOPHENYL) SULFONE, BIS(4-AMINOPHENYL)SULPHONE, BIS(P-AMINOPHENYL) SULFONE, BIS(P-AMINOPHENYL)SULPHONE, CROYSULFONE, CROYSULPHONE, DADPS, DAPSON, DAPSONE, DAPSONUM, DDS, DDS (PHARMACEUTICAL), DDS (VAN), DI(4-AMINOPHENYL) SULFONE, DI(4-AMINOPHENYL)SULFONE, DI(4-AMINOPHENYL)SULPHONE, DI(P-AMINOPHENYL) SULFONE, DI(P-AMINOPHENYL)SULPHONE, DIAMINO-4,4'-DIPHENYL SULFONE, DIAMINO-4,4'-DIPHENYL SULPHONE, DIAPHENYLSULFON, DIAPHENYLSULFONE, DIAPHENYLSULPHON, DIAPHENYLSULPHONE, DIPHENASONE, DIPHONE, DISULONE, DSS, DUBRONAX, DUMITONE, EPORAL, F 1358, HARDENER HT 976, HT 9664, HT 976, ICI, MALOPRIM, METABOLITE C, NCI-C01718, NOVOPHONE, NSC 6091, NSC 6091D, NSC-6091, P,P'-DIAMINODIPHENYL SULFONE, P,P'-DIAMINODIPHENYL SULPHONE, P,P'-SULFONYLBISBENZAMINE, P,P'-SULFONYLDIANILINE, P,P'-SULPHONYLBISBENZAMINE, P,P'-SULPHONYLBISBENZENAMINE, P,P'-SULPHONYLDIANILINE, P-AMINOPHENYL SULFONE, SEIKACURE S, SULFONA, SULFONA-MAE, SULFONE UCB, SULPHADIONE, SULPHON-MERE, SULPHONYLDIANILINE, SUMICURE S, TARIMYL, UDOLAC, WR 448 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 248.32 | L | 176 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.087 | 0.96 | 7.7 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.88 | 9.7 | 78 |
Technical Basis
A review of available sources found multiple toxicity data points. For TEEL-3, rat oral LD50 (1955) and rat intraperitoneal LD50 (1970) were compared. The oral route is preferred (See Section 3.3.2,) but the more recent data was selected as the basis for the TEEL-3. There were several published human oral toxic doses (TDLo, 1983.) When compared, one case reported only one subject, while the another was a clinical study involving three subjects; the three subject study was also a more conservative value. This is the TDLo that was selected for the TEEL-2 basis. The toxic endpoints included thorax cyanosis (respiration) and methemoglobinemia-carboxyhemoglobin (blood), which should both be reviewed as appropriate for TEEL development. The TEEL-1 value was calculated from the TEEL-2 value, in accordance with guidelines in the handbook (see table 3.5.)
TEEL-1 = TEEL-2/11
TEEL-2 = Human (female) oral TDLo (18 mg/kg)
TEEL-3 = Rat intraperitoneal LD50 (196 mg/kg)
This review generated a TEEL-3 which is consistent with those reported in Rev. 29A. The recommended TEEL-2 and TEEL-1 values are more conservative than Rev. 29A. In Rev. 29A the TEEL-2 was derived from the single subject TDLo described above, while the current recommendation is a TEEL-2 basis that includes three subjects in a clinical study which also had a more conservative dose reported.
TEEL-1 = TEEL-2/11
TEEL-2 = Human (female) oral TDLo (18 mg/kg)
TEEL-3 = Rat intraperitoneal LD50 (196 mg/kg)
This review generated a TEEL-3 which is consistent with those reported in Rev. 29A. The recommended TEEL-2 and TEEL-1 values are more conservative than Rev. 29A. In Rev. 29A the TEEL-2 was derived from the single subject TDLo described above, while the current recommendation is a TEEL-2 basis that includes three subjects in a clinical study which also had a more conservative dose reported.
References
https://pubchem.ncbi.nlm.nih.gov/compound/2955