PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dichloroacetic acid | 79-43-6 | 1764 |
14.01
4.01
11.01
14.02
4.05
7.01
4.09
4.10
4.07
2.00
|
|||||||||
| Formula | Synonyms | |||||||||||
| C2.Cl2.H2.O2 | DICHLOROACETIC ACID, 2,2-DICHLOROACETIC ACID, ACETIC ACID, DICHLORO-, ACIDE DICHLORACÉTIQUE (DOT FRENCH), ACIDO DICLOROACÉTICO (DOT SPANISH), BICHLORACETIC ACID, DCA, DCA (ACID), DICHLORACETIC ACID, DICHLORETHANOIC ACID, DICHLOROETHANOIC ACID, DKHUK, UN 1764, URNER^S LIQUID | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 128.95 | L | 10 | 194 | 1 | 44 | 1.5634 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 7.9 | 93 | 560 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.5 | 18 | 110 |
Technical Basis
A review of available sources identified the following TLV-TWA and LD50 data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Of the available LD50, a rat oral LD50 was the most preferred species and route and was therefore selected as the TEEL-3 basis. TEEL-2 values were derived according to Table 3.5. The TLV-TWA was selected as the TEEL-1 basis.
• TEEL-1 = TLV-TWA (0.5 ppm) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (2820 mg/kg)
This review generated a TEEL-1 value consistent with Rev. 29A. The TEEL-3 bases are the same (rat oral LD50) but current research identified a lower dose. The TEEL-2 dog oral TDLo basis used in Rev. 29A was not found in this analysis.
• TEEL-1 = TLV-TWA (0.5 ppm) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (2820 mg/kg)
This review generated a TEEL-1 value consistent with Rev. 29A. The TEEL-3 bases are the same (rat oral LD50) but current research identified a lower dose. The TEEL-2 dog oral TDLo basis used in Rev. 29A was not found in this analysis.
References
https://cameochemicals.noaa.gov/chemical/532
AMA Archives of Industrial Hygiene and Occupational Medicine., 4(119), 1951; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 6597, Dichloroacetic acid. Retrieved from Section 13.1.11 (Acute Effects) https://pubchem.ncbi.nlm.nih.gov/compound/Dichloroacetic-acid.
American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH 2017, p. 25; retrieved from https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6894#section=Threshold-Limit-Values-(TLV)-(Complete)