Technical Basis
A review of available sources identified the following: PEL-C, TLV-C, REL-C, OEL-STELs and TLVs, and acute toxicity data (LC50, LCLo) for several species. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The most preferred species, route, and duration toxicity data, a 1-hour mouse LC50, was selected as the TEEL-3 basis. The TLV-C was selected as the TEEL-2. A TEEL-1 value was derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = 0.1 ppm TLV-C
• TEEL-3 = Mouse LC50 (124 ppm/1H)
This review generated TEEL values that are consistent with Rev. 29A.
References
Reichert D, Ewald D, Henschler D. 1975. Generation and inhalation toxicity of dichloroacetylene. Food Cosmet Toxicol 13:511-515. Retreived from page 109 of: https://www.ecetoc.org/wp-content/uploads/2021/10/ECETOC-TR-103.pdf
Exposure limits (TLV-C): https://www.osha.gov/chemicaldata/596
OEL. Retrieved from: https://ilv.ifa.dguv.de/limitvalues/18236
Chemical Information: https://pubchem.ncbi.nlm.nih.gov/compound/Dichloroacetylene