PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dichloroethanol acetate, 1,2- | 10140-87-1 |
14.01
11.01
14.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| C4.H6.Cl2.O2 | ETHANOL, 1,2-DICHLORO-, ACETATE, 1,2-DICHLOROETHYL ACETATE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 157 | L | 1.296 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.010 | 0.11 | 0.69 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.064 | 0.71 | 4.4 |
Technical Basis
A review of available sources identified rat LCLo acute toxicity data and a LOC. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The 6-hour rat LCLo was selected as the TEEL-3 basis. The LOC was evaluated for the TEEL-2 but resulted in a TEEL-2 > TEEL-3 when considering the rat LCLo as the TEEL-3 basis; therefore, it was not selected. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat LCLo (16 ppm/4H)
This review generated PAC values inconsistent with Rev. 29A. In Rev. 29A the TEEL-2 was the LOC, and the TEEL-3 was derived from the TEEL-2 (Table 3.5); however, the current TEEL-3 is based on rat inhalation toxicity data (LCLo) and derived the TEEL-2 according to Table 3.5 The Rev. 29A and current TEEL-1 use the same methodology, with differences due to the change in the TEEL-2 basis.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat LCLo (16 ppm/4H)
This review generated PAC values inconsistent with Rev. 29A. In Rev. 29A the TEEL-2 was the LOC, and the TEEL-3 was derived from the TEEL-2 (Table 3.5); however, the current TEEL-3 is based on rat inhalation toxicity data (LCLo) and derived the TEEL-2 according to Table 3.5 The Rev. 29A and current TEEL-1 use the same methodology, with differences due to the change in the TEEL-2 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/1_2-Dichloroethyl-acetate.
Journal of Industrial Hygiene and Toxicology., 31(343), 1949 [PMID:15407114] Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/1_2-Dichloroethyl-acetate.
LOC: Appendix C (page C-4); https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf