PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dichloroisopropyl ether | 108-60-1 | 2490 |
15.01
4.01
11.01
15.02
7.01
8.00
11.00
4.09
4.10
3.05
|
|||||||||
| Formula | Synonyms | |||||||||||
| C6H12Cl2O | BIS(2-CHLORO-1-METHYLETHYL)ETHER, (2-CHLORO-1-METHYLETHYL) ETHER, 2,2^-DICHLORODIISOPROPYL ETHER, 2,2'-DICHLOROISOPROPYL ETHER, 2,2'-OXYBIS(1-CHLOROPROPANE), BETA,BETA'-DICHLORODIISOPROPYL ETHER, BIS(1-CHLORO-2-PROPYL) ETHER, BIS(2-CHLORO-1-METHYLETHYL) ETHER, BIS(2-CHLOROISOPROPYL) ETHER, BIS(BETA-CHLOROISOPROPYL)ETHER, DCIP, DCIP (NEMATOCIDE), DICHLORODIISOPROPYL ETHER, DICHLOROISOPROPYL ETHER, ETHER, BIS(2-CHLORO-1-METHYLETHYL), NCI-C50044, NEMAMORT, PROPANE, 2,2'-OXYBIS(1-CHLORO-, RCRA WASTE NUMBER U027, UN 2490 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 171.06 | L | 187 | 0.75 | 27.3 | 1.103 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.49 | 5.4 | 32 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.4 | 38 | 220 |
Technical Basis
A review of available sources identified acute toxicity data (LD50, LCLo) for various routes (inhalation, oral, dermal) and species (rat, mouse, rabbit). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled down to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The data of the most preferred route and species, a 5-hour rat LCLo, was selected as the TEEL-3 basis. TEEL-2 and -1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat LCLo (700 ppm/5H)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a 1-hour rat LCLo; however, that dose could not be found in the current review and instead a less conservative dose was used. Similarly, the Rev. 29A TEEL-2 basis was a rat oral TDLo that was also not found in this review; it was instead calculated according to Table 3.5. The TEEL-1 methodology remains consistent, with the difference in value due to the change of the TEEL-2 basis.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat LCLo (700 ppm/5H)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a 1-hour rat LCLo; however, that dose could not be found in the current review and instead a less conservative dose was used. Similarly, the Rev. 29A TEEL-2 basis was a rat oral TDLo that was also not found in this review; it was instead calculated according to Table 3.5. The TEEL-1 methodology remains consistent, with the difference in value due to the change of the TEEL-2 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Bis_2-chloro-1-methylethyl_-ether.
Rat LCLo: British Journal of Industrial Medicine., 27(1), 1970 [PMID:5418916] Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Bis_2-chloro-1-methylethyl_-ether.