PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dichloromethoxy ethane; (bis(2-Chloroethoxy)methane) | 111-91-1 | 2810 |
15.01
15.02
8.00
3.08
7.11
10.00
3.09
3.10
3.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C5.H10.Cl2.O2 | BIS(2-CHLOROETHOXY)METHANE, [LIQUID], 1,1^-[METHYLENE BIS(OXY)]BIS[2-CHLOROETHANE], 1,7-DICHLORO-3,5-DIOXAHEPTANE, BIS(2-CHLOROETHOXY) METHANE, BIS(2-CHLOROETHOXY)METHANE, BIS(2-CHLOROETHYL) FORMAL, BIS(BETA-CHLOROETHYL) FORMAL, BIS(BETA-CHLOROETHYL)FORMAL, DI(2-CHLOROETHOXY)METHANE, DI-2-CHLOROETHYL FORMAL, DICHLORODIETHYL FORMAL, DICHLOROETHYL FORMAL, FORMALDEHYDE BIS(2-CHLOROETHYL) ACETAL, FORMALDEHYDE BIS(BETA-CHLOROETHYL) ACETAL, METHANE, BIS(2-CHLOROETHOXY)- | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 173.05 | L | -32.8 | 217.5 | 0.1 | 20 | 1.2339 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.033 | 0.37 | 2.2 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0047 | 0.052 | 0.31 |
Technical Basis
A review of available sources identified acute toxicity data (LC50, LCLo, and LD50) for several species. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The most preferred inhalation source, a rat LC50, was selected as the TEEL-3 basis. This dose was reported as a range (>0.05 - ≤ 0.5 mg/L/4H), therefore the lower limit of the range was used for TEEL calculations (>0.5 mg/L/4H). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LC50 (>0.05 mg/L/4H)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat LCLo (62 ppm/4H), while the current basis is a higher priority source for inhalation data (Table 3.1, LC50 > LCLo). The Rev. 29A and current TEEL-2/TEEL-1 values were derived using the same methodology (Table 3.5), with differences due to the change in TEEL-3.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LC50 (>0.05 mg/L/4H)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat LCLo (62 ppm/4H), while the current basis is a higher priority source for inhalation data (Table 3.1, LC50 > LCLo). The Rev. 29A and current TEEL-2/TEEL-1 values were derived using the same methodology (Table 3.5), with differences due to the change in TEEL-3.
References
Journal of Industrial Hygiene and Toxicology., 31(343), 1949 [PMID:15407114]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Bis_2-chloroethoxy_methane.
Rat LC¬50. Retrieved from: https://echa.europa.eu/registration-dossier/-/registered-dossier/13289/7/3/3