PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dicyclohexano-18-crown-6 | 16069-36-6 |
6.00
15.01
11.01
7.01
7.00
11.00
4.10
3.08
3.09
3.04
|
||||||||||
| Formula | Synonyms | |||||||||||
| C20H36O6 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 372.56 | S wax | 344 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.53 | 5.8 | 35 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.035 | 0.38 | 2.3 |
Technical Basis
A review of available sources identified multiple rat, mouse, and rabbit acute toxicity data (LD50, LDLo) for various routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred route and species toxicity data, a rat oral LD50, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (176 mg/kg)
This review generated a TEEL-2 and TEEL-1 values inconsistent with Rev. 29A. The TEEL-3 source, methodology, and value is consistent with Rev. 29A. The Rev. 29A TEEL-2 basis, a rat oral TDLo, was not found in this review; instead, the current TEEL-2 was derived according to Table 3.5. The Rev. 29A and current TEEL-1 use the same methodology, with differences due to the change in the TEEL-2.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (176 mg/kg)
This review generated a TEEL-2 and TEEL-1 values inconsistent with Rev. 29A. The TEEL-3 source, methodology, and value is consistent with Rev. 29A. The Rev. 29A TEEL-2 basis, a rat oral TDLo, was not found in this review; instead, the current TEEL-2 was derived according to Table 3.5. The Rev. 29A and current TEEL-1 use the same methodology, with differences due to the change in the TEEL-2.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Dicyclohexano-18-crown-6.
Rat oral LD50: Drug and Chemical Toxicology., 8(451), 1985 [PMID:4092618]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Dicyclohexano-18-crown-6.
RTECS archive: via ChemSrc; https://www.chemsrc.com/en/cas/16069-36-6_404019.html