PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Diethylaminoacetone 1620-14-0
15.01
11.01
15.02
Formula Synonyms
C7H15NO
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
129
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.62 6.9 41
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.12 1.3 7.8
Technical Basis
A review of limited sources identified GHS health hazards for diethylaminoacetone. Additionally, a similar chemical (novol ketone, C9H19NO, CASRN: 105-14-6) acute toxicity data was evaluated as a TEEL-3 basis for this chemical. Data sources were selected according to the hierarchy listed in Table 3.1. Two of the three GHS health hazard categories are 2 (H315, H319), indicating an approximate HHR=3 (79 mg/m3). Considering the TEEL magnitude indicated by GHS health hazard categories, the mouse intravenous LD50 for a similar chemical, (novol ketone) was selected as the TEEL-3 basis for diethylaminoacetone (Section 3.4.6). This toxicity data was evaluated using factors in Tables 3.2, 3.3, and 3.4. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse intravenous LD50 (CASRN: 105-14-6, 190 mg/kg)
This review generated TEEL-3 and TEEL-2 values that are consistent with Rev. 29A. Minor differences in TEEL-1 values may be due to rounding.
References
https://pubchem.ncbi.nlm.nih.gov/compound/Diethylamino_acetone.
Mouse intravenous LD50 (novol ketone, CASRN: 1620-14-0). Archives Internationales de Pharmacodynamie et de Therapie., 145(233), 1963 [PMID:14077686]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/5-Diethylamino-2-pentanone.
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.